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CS-W001157 4
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N3-PEG3-C2-NHS ester

  • CAS No. 1245718-89-1

  • Cat. No. CS-0105091
  • Purity≥95%
  • MDL No.MFCD23726613

*For research and further manufacturing use only, not for direct human use.

N3-PEG3-C2-NHS ester|CS-0105091

Structure of 1245718-89-1

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General Information

  • CAS No. 1245718-89-1
  • Cat. No. CS-0105091
  • Purity ≥95%
  • MDL No. MFCD23726613
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀N₄O₇
  • Molecular Weight 344.32
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCN=[N+]=[N-]

Description

N3-PEG3-C2-NHS ester enables efficient, site-specific conjugation in bioconjugation workflows. This bifunctional reagent combines a reactive NHS ester with a triazole-forming azide group, linked via a short PEG spacer. The hydrophilic PEG chain enhances solubility and reduces non-specific binding, while the stable triazole linkage forms under mild conditions. Ideal for labeling proteins, peptides, and biomolecules with minimal aggregation.

Application

N3-PEG3-C2-NHS ester serves as a versatile bifunctional linker for site-specific conjugation in synthetic biology and medicinal chemistry. The NHS ester moiety enables efficient coupling to primary amines under physiological conditions, while the terminal azide group facilitates selective click reactions with alkyne-bearing partners. This PEG3-spaced reagent offers enhanced solubility, stability, and ease of purification, making it ideal for constructing bioconjugates, peptide-drug hybrids, and functionalized biomaterials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   140.13
  • LogP   0.3438
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   13

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