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6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-6-ol

  • CAS No. 1378606-06-4

  • Cat. No. CS-0096474
  • Purity≥98%
  • MDL No.MFCD14706473

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-6-ol|CS-0096474

Structure of 1378606-06-4

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General Information

  • CAS No. 1378606-06-4
  • Cat. No. CS-0096474
  • Purity ≥98%
  • MDL No. MFCD14706473
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) None
  • SMILES OC1CC2=NC=CN2C1

Description

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-6-ol is a bench-stable heterocyclic scaffold featuring a fused imidazole ring system with a hydroxyl group at the 6-position. This electron-rich core integrates readily into bioactive molecule design, offering enhanced solubility and hydrogen-bonding capacity for medicinal chemistry applications.

Application

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-6-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of nitrogen-rich scaffolds relevant to kinase inhibitors and CNS-targeted therapeutics. Its hydroxyl group facilitates downstream functionalization via esterification or ether formation, while the fused imidazole core exhibits robust bench stability and compatibility with standard coupling reactions. Functions effectively in both solution-phase and solid-phase synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   -0.1999
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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