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CS-W001157 4
Total: USD 88.00

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole

  • CAS No. 59646-16-1

  • Cat. No. CS-0100195
  • Purity≥97%
  • MDL No.MFCD11870771

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole|CS-0100195

Structure of 59646-16-1

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General Information

  • CAS No. 59646-16-1
  • Cat. No. CS-0100195
  • Purity ≥97%
  • MDL No. MFCD11870771
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂
  • Molecular Weight 108.14
  • Synonym(s) 5H,6H,7H-pyrrolo[1,2-a]iMidazole
  • SMILES C12=NC=CN1CCC2

Description

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole is a nitrogen-rich heterocycle featuring a fused imidazole and pyrrole core. This scaffold exhibits enhanced stability and electron-donating character, enabling its integration into functional materials and bioactive compound libraries. The saturated six-membered ring facilitates synthetic versatility under standard conditions.

Application

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to biologically relevant imidazolyl frameworks. Its stable, bench-friendly structure facilitates diverse functionalization at the 2- and 3-positions, supporting standard coupling reactions and transition-metal-catalyzed transformations. The compound functions as a key building block in the synthesis of kinase inhibitors and other targeted therapeutics, offering predictable reactivity and compatibility with common protecting group strategies.

Synthesis

  • Route1
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      137415-92-0
    • ~%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole|CS-0100195
      59646-16-1
    • In-stock
      5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine|CS-0138089
      34167-66-3

    References

    • US5039691 A1, ; US 5039691 A
  • Route2
    • null|null
      616-45-5
    • null|null
      645-36-3
    • ~80%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole|CS-0100195
      59646-16-1

    References

    • Hua, Duy H.; Zhang, Fengqi; Chen, Jinshan; Robinson, Paul D. Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 5084 - 5087
  • Route3
    • null|null
      191542-46-8
    • ~51%
    • In-stock
      6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole|CS-0100195
      59646-16-1

    References

    • Aldabbagh, Fawaz; Bowman, W. Russell Tetrahedron, 1999 , vol. 55, # 13 p. 4109 - 4122

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   0.8293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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