DMT-2'-F-Bz-dA

Name: DMT-2'-F-Bz-dA
Brand: ChemScene
Availability: InStock
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CAS No. 136834-21-4
Cat. No. CS-0139662
Purity≥95%
MDL No.MFCD15145191

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 136834-21-4

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Description

DMT-2'-F-Bz-dA is a protected nucleoside building block featuring a 2'-fluorinated sugar and a benzoyl group at the 5'-position, enabling efficient incorporation into oligonucleotide synthesis. The dimethoxytrityl (DMT) group at the 5'-end facilitates purification and monitoring during solid-phase assembly. This derivative combines enhanced nuclease resistance with improved hybridization affinity, making it ideal for antisense and siRNA applications.

Application

DMT-2'-F-Bz-dA serves as a key building block for the synthesis of modified oligonucleotides, enabling site-specific incorporation of 2'-fluoro and benzoyl-protected deoxyadenosine residues. The DMT group provides orthogonal protection for the 5'-OH, facilitating efficient solid-phase synthesis, while the 2'-F substituent enhances nuclease resistance and duplex stability. The benzoyl group offers reliable protection during coupling steps, with straightforward removal under mild basic conditions. This derivative is particularly valuable in the construction of antisense oligonucleotides and nucleic acid therapeutics requiring enhanced metabolic stability and binding affinity.

General Information

CAS No. 136834-21-4
Cat. No. CS-0139662
Purity ≥95%
MDL No. MFCD15145191
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₈H₃₄FN₅O₆
Molecular Weight 675.70
Synonym(s) None
SMILES O[C@H]1[C@@H](F)[C@H](N2C(N=CN=C3NC(C4=CC=CC=C4)=O)=C3N=C2)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

Computational Chemistry Data

TPSA 129.85
LogP 5.7009
H_Acceptors 10
H_Donors 2
Rotatable_Bonds 11

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Nucleosides & Nucleotides 2'-F-phosphoramidite monomer

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Key Words

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DMT-2'-F-Bz-dA

CAS No. 136834-21-4

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