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CS-W001157 4
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DMT-2'fluoro-da(bz) amidite

  • CAS No. 136834-22-5

  • Cat. No. CS-B1581
  • Purity≥95%
  • MDL No.MFCD12912392

*For research and further manufacturing use only, not for direct human use.

DMT-2'fluoro-da(bz) amidite|CS-B1581

Structure of 136834-22-5

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General Information

  • CAS No. 136834-22-5
  • Cat. No. CS-B1581
  • Purity ≥95%
  • MDL No. MFCD12912392
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₇H₅₁FN₇O₇P
  • Molecular Weight 875.92
  • Synonym(s) None
  • SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N5C6=NC=NC(NC(C7=CC=CC=C7)=O)=C6N=C5)O4

Description

DMT-2′-fluoro-dA(bz) amidite delivers a protected 2′-fluoro-modified adenosine building block with enhanced nuclease resistance and improved duplex stability. The benzoyl group at the N6 position ensures selective incorporation during solid-phase synthesis, while the DMT protecting group enables efficient purification and stepwise chain elongation under standard conditions.

Application

DMT-2'-fluoro-dA(Bz) amidite serves as a key building block for the solid-phase synthesis of oligonucleotides incorporating 2'-fluoro-modified adenosine residues. The DMT group provides orthogonal protection for the 5'-end, enabling efficient deprotection and purification post-synthesis. The 2'-fluoro substitution enhances nuclease resistance and improves binding affinity to complementary RNA targets, while the benzoyl (Bz) group ensures reliable base protection during synthesis. This amidite exhibits excellent coupling efficiency and stability under standard phosphoramidite conditions, making it well-suited for routine use in the construction of therapeutic and research oligonucleotides.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   155.11
  • LogP   9.00118
  • H_Acceptors   13
  • H_Donors   1
  • Rotatable_Bonds   19

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