Lot numbers can be found on the outside label of a product:
2'-O-MOE-5-Me-rU
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CAS No. 163759-49-7
- Cat. No. CS-0100774
- Purity≥97%
- MDL No.MFCD02682964
*For research and further manufacturing use only, not for direct human use.
Structure of 163759-49-7
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General Information
- CAS No. 163759-49-7
- Cat. No. CS-0100774
- Purity ≥97%
- MDL No. MFCD02682964
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₂₀N₂O₇
- Molecular Weight 316.31
- Synonym(s) None
- SMILES O[C@H]1[C@@H](OCCOC)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
Description
2'-O-MOE-5-Me-rU is a modified ribonucleoside featuring a 2'-O-methoxyethyl group and a methyl substituent at the 5-position of uracil. This combination enhances nuclease resistance and binding affinity while maintaining favorable pharmacokinetic properties. The moiety integrates seamlessly into oligonucleotide sequences for therapeutic applications.
Application
2'-O-MOE-5-Me-rU serves as a robust nucleoside building block for antisense oligonucleotide synthesis, combining the enhanced nuclease resistance of 2'-O-methoxyethyl (MOE) modification with the stabilizing effect of 5-methylcytosine analogs. Its improved pharmacokinetic profile and compatibility with standard phosphoramidite chemistry facilitate efficient incorporation into therapeutic sequences, enabling prolonged target engagement in clinical applications.
Synthesis
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Route1
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In-stock
22423-26-3 -
14983-42-7 - ~70%
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In-stock
163759-49-7
References
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Isis Pharmaceuticals Inc. Patent: US2003/225015 A1, 2003 ; Location in patent: Page 18-19 ;
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Route2
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947322-40-9 -
14983-42-7
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109-86-4
- ~70%
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In-stock
163759-49-7
References
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Isis Pharmaceuticals Inc. Patent: US2004/29273 A1, 2004 ; Location in patent: Page/Page column 18-19 ; US 20040029273 A1
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Route3
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14983-42-7
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215713-37-4
- ~69%
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In-stock
163759-49-7
References
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Isis Pharmaceuticals, Inc. Patent: US2004/14699 A1, 2004 ; Location in patent: Page/Page column 18 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 123.01
- LogP -1.87278
- H_Acceptors 8
- H_Donors 3
- Rotatable_Bonds 6
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Key Words
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