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CS-W001157 4
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2-(Trifluoromethyl)thiazol-5-amine

  • CAS No. 1367944-72-6

  • Cat. No. CS-0157305
  • Molecule weight168.14
  • Purity≥98%
  • MDL No.MFCD11847091

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)thiazol-5-amine|CS-0157305

Structure of 1367944-72-6

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General Information

  • CAS No. 1367944-72-6
  • Cat. No. CS-0157305
  • Purity ≥98%
  • MDL No. MFCD11847091
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃F₃N₂S
  • Molecular Weight 168.14
  • Synonym(s) 2-(Trifluoromethyl)-1,3-thiazol-5-amine
  • SMILES C1=C(N)SC(=N1)C(F)(F)F

Description

2-(Trifluoromethyl)thiazol-5-amine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, enabling its use in constructing bioactive heterocycles. The thiazole scaffold provides a rigid, planar framework ideal for pharmaceutical applications. This compound serves as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and antiparasitic agents.

Application

2-(Trifluoromethyl)thiazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the amine functionality facilitates diverse coupling reactions. The scaffold exhibits robust bench stability and compatibility with standard synthetic protocols, making it well-suited for parallel library synthesis and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.7441
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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