Lot numbers can be found on the outside label of a product:
2-Methylthiazol-5-amine
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CAS No. 89281-44-7
- Cat. No. CS-W006129
- Purity≥97%
- MDL No.MFCD11847087
*For research and further manufacturing use only, not for direct human use.
Structure of 89281-44-7
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General Information
- CAS No. 89281-44-7
- Cat. No. CS-W006129
- Purity ≥97%
- MDL No. MFCD11847087
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₆N₂S
- Molecular Weight 114.17
- Synonym(s) 5-Amino-2-methylthiazole
- SMILES NC1=CN=C(C)S1
Description
2-Methylthiazol-5-amine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a thiazole ring with a methyl group at the 2-position and an amino substituent at the 5-position. This configuration imparts favorable solubility and metabolic stability, enabling efficient incorporation into bioactive molecules. The compound acts as a versatile building block for drug discovery programs targeting kinase inhibitors and antimicrobial agents.
Application
2-Methylthiazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its amino group facilitates direct functionalization and coupling reactions, while the methyl substituent enhances metabolic stability and lipophilicity. The compound exhibits good bench stability and compatibility with standard synthetic protocols, making it valuable for library synthesis and lead optimization in drug discovery programs.
Synthesis
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Route1
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870-73-5 - ~50%
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In-stock
89281-44-7
References
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ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/71955 A1, 2007 ; Location in patent: Page/Page column 48 ; WO 2007/071955 A1
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Route2
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870-73-5
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151-63-3 - ~%
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In-stock
89281-44-7
References
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Scott, David A.; Aquila, Brian M.; Bebernitz, Geraldine A.; Cook, Donald J.; Dakin, Les A.; Deegan, Tracy L.; Hattersley, Maureen M.; Ioannidis, Stephanos; Lyne, Paul D.; Omer, Charles A.; Ye, Minwei; Zheng, XiaoLan Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4794 - 4797
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Route3
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594-03-6 -
In-stock
540-61-4 - ~%
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In-stock
89281-44-7
References
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Sych,E.D.; Umanskaya,L.P. J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, p. 2068 - 2074,2080 - 2085
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 1.03372
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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