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tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate

  • CAS No. 1359704-84-9

  • Cat. No. CS-0048403
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate|CS-0048403

Structure of 1359704-84-9

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General Information

  • CAS No. 1359704-84-9
  • Cat. No. CS-0048403
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁NO₃
  • Molecular Weight 239.31
  • Synonym(s) 6-Boc-6-azaspiro[3.5]nonan-2-one
  • SMILES CC(C)(C)OC(=O)N1CCCC2(CC(=O)C2)C1

Description

tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate is a sterically hindered spirocyclic ketone featuring a nitrogen atom at the bridgehead position. This configuration imparts enhanced stability and facilitates selective functionalization in complex molecular architectures. The tert-butyl ester group enables straightforward deprotection under mild acidic conditions, streamlining access to the corresponding carboxylic acid.

Application

tert-Butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry, enabling access to nitrogen-containing heterocycles via controlled reductive amination and cyclization. The protected ketone and amine functionalities exhibit excellent functional group tolerance, facilitating downstream transformations. Bench-stable and readily purified by chromatography, it supports scalable synthesis of complex scaffolds relevant to drug discovery programs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.3666
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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