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CS-W001157 4
Total: USD 88.00

Tert-butyl 8-oxo-2-azaspiro[5.5]Undecane-2-carboxylate

  • CAS No. 2306276-55-9

  • Cat. No. CS-0500409
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 8-oxo-2-azaspiro[5.5]Undecane-2-carboxylate|CS-0500409

Structure of 2306276-55-9

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General Information

  • CAS No. 2306276-55-9
  • Cat. No. CS-0500409
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₅NO₃
  • Molecular Weight 267.36
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1CCCC2(CCCC(=O)C2)C1

Description

Tert-butyl 8-oxo-2-azaspiro[5.5]undecane-2-carboxylate is a sterically encumbered spirocyclic scaffold featuring a ketone at C8 and a protected carboxylic acid at C2. This configuration enables direct functionalization at the azaspiro core, supporting rapid access to complex heterocycles in medicinal chemistry campaigns. The tert-butyl ester enhances solubility and stability under standard bench conditions.

Application

Tert-butyl 8-oxo-2-azaspiro[5.5]undecane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry applications, featuring a ketone at C8 and a protected amine at N2. The tert-butyl ester enables straightforward deprotection under mild acidic conditions, while the spirocyclic core provides conformational rigidity and enhanced metabolic stability. It functions effectively in standard functional group interconversions and supports diverse downstream transformations relevant to heterocycle-based drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   3.1468
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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