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CS-W001157 4
Total: USD 88.00

2-(Methylamino)pyridine-4-boronic acid pinacol ester

  • CAS No. 1350913-08-4

  • Cat. No. CS-0183543
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Methylamino)pyridine-4-boronic acid pinacol ester|CS-0183543

Structure of 1350913-08-4

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General Information

  • CAS No. 1350913-08-4
  • Cat. No. CS-0183543
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉BN₂O₂
  • Molecular Weight 234.10
  • Synonym(s) N-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridin-2-amine
  • SMILES N=1C=CC(=CC1NC)B2OC(C)(C)C(O2)(C)C

Description

2-(Methylamino)pyridine-4-boronic acid pinacol ester delivers a boronate moiety flanked by a methylamino-substituted pyridine, enabling efficient coupling in Suzuki-Miyaura reactions. This bench-stable, moisture-tolerant reagent integrates seamlessly into complex molecule assembly workflows, offering high functional group compatibility and reliable yield under standard conditions.

Application

2-(Methylamino)pyridine-4-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. The pinacol boronate ester enables reliable C–C bond formation under mild conditions, while the pyridyl-methylamino moiety provides orthogonal reactivity and enhanced solubility. It functions effectively in late-stage functionalization and heterocyclic scaffold elaboration, offering predictable regiochemistry and compatibility with diverse reaction partners.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.38
  • LogP   1.4225
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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