1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Name: 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
Brand: ChemScene
Availability: InStock
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CAS No. 1220696-38-7
Cat. No. CS-0041240
Purity≥95%
MDL No.MFCD18383773

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1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one|CS-0041240

Structure of 1220696-38-7

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General Information

CAS No. 1220696-38-7
Cat. No. CS-0041240
Purity ≥95%
MDL No. MFCD18383773
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₀BNO₃
Molecular Weight 273.14
Synonym(s) None
SMILES O=C1N(C)C2=C(C=C(B3OC(C)(C)C(C)(C)O3)C=C2)C1

Description

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one features a boronate ester group enabling efficient Suzuki-Miyaura coupling under mild conditions. This bench-stable reagent integrates readily into complex molecular architectures, offering high functional group tolerance and predictable reactivity in C–C bond formation workflows.

Application

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The indolin-2-one core provides a privileged scaffold in medicinal chemistry, while the tetramethylboronate group enables efficient C–C bond formation under mild conditions. Functional group tolerance and ease of purification make it ideal for rapid diversification in drug discovery workflows.

Synthesis

Route1
- In-stock
  
  20870-90-0
- In-stock
  
  73183-34-3
- ~%
- In-stock
  
  1220696-38-7
References
- NOVARTIS AG; ADAMS, Christopher Michael; CHAMOIN, Sylvie; HU, Qi-Ying; ZHANG, Chun Patent: WO2010/130794 A1, 2010 ; Location in patent: Page/Page column 54; 55 ; WO 2010/130794 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.77
LogP 1.5047
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

CAS No. 1220696-38-7

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