Lot numbers can be found on the outside label of a product:
tert-Butyl (2-hydroxy-1-phenylethyl)carbamate
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CAS No. 67341-01-9
- Cat. No. CS-W022966
- Purity≥97%
- MDL No.MFCD01883039
*For research and further manufacturing use only, not for direct human use.
Structure of 67341-01-9
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General Information
- CAS No. 67341-01-9
- Cat. No. CS-W022966
- Purity ≥97%
- MDL No. MFCD01883039
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₁₉NO₃
- Molecular Weight 237.30
- Synonym(s) N-Boc-DL-2-phenylglycinol
- SMILES O=C(OC(C)(C)C)NC(C1=CC=CC=C1)CO
Description
tert-Butyl (2-hydroxy-1-phenylethyl)carbamate delivers a protected hydroxyl group flanked by a chiral benzylic center, enabling stereocontrolled synthesis in complex molecule assembly. The carbamate moiety ensures stable protection under standard conditions while permitting selective deprotection via mild acidolysis. This scaffold integrates seamlessly into peptide and natural product frameworks, offering enhanced solubility and handling advantages in synthetic workflows.
Application
tert-Butyl (2-hydroxy-1-phenylethyl)carbamate serves as a stable, bench-friendly chiral auxiliary for asymmetric synthesis, enabling stereoselective transformations via its protected hydroxyl and amine functionalities. The carbamate group facilitates efficient deprotection under mild acidic conditions, while the pendant phenyl and hydroxyl moieties support orthogonal functionalization in complex molecule assembly. Its robust stability and predictable reactivity make it a reliable building block for pharmaceutical intermediates and natural product synthesis.
Synthesis
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References
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Skerlj, Renato; Bridger, Gary; Zhou, Yuanxi; Bourque, Elyse; McEachern, Ernest; Metz, Markus; Harwig, Curtis; Li, Tong-Shuang; Yang, Wen; Bogucki, David; Zhu, Yongbao; Langille, Jonathan; Veale, Duane; Ba, Tuya; Bey, Michael; Baird, Ian; Kaller, Alan; Krumpak, Maria; Leitch, David; Satori, Michael; Vocadlo, Krystyna; Guay, Danielle; Nan, Susan; Yee, Helen; Crawford, Jason; Chen, Gang; Wilson, Trevor; Carpenter, Bryon; Gauthier, David; MacFarland, Ron; Mosi, Renee; Bodart, Veronique; Wong, Rebecca; Fricker, Simon; Schols, Dominique Journal of Medicinal Chemistry, 2013 , vol. 56, # 20 p. 8049 - 8065
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Route2
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402741-11-1 - ~99%
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117049-14-6 -
In-stock
67341-01-9
References
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List, Benjamin; Pojarliev, Peter; Biller, William T.; Martin, Harry J. Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 827 - 833
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Route3
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510730-65-1
- ~95%
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In-stock
67341-01-9
References
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Chakraborty, Tushar K.; Ghosh, Animesh Tetrahedron Letters, 2002 , vol. 43, # 52 p. 9691 - 9693
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 58.56
- LogP 2.2447
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 3
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Key Words
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