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CS-W001157 4
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Acid-C2-PEG4-C2-NHS ester

  • CAS No. 1343476-41-4

  • Cat. No. CS-0107924
  • Purity≥98%
  • MDL No.MFCD27952888

*For research and further manufacturing use only, not for direct human use.

Acid-C2-PEG4-C2-NHS ester|CS-0107924

Structure of 1343476-41-4

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General Information

  • CAS No. 1343476-41-4
  • Cat. No. CS-0107924
  • Purity ≥98%
  • MDL No. MFCD27952888
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₉NO₁₁
  • Molecular Weight 435.42
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCC(O)=O

Description

Acid-C2-PEG4-C2-NHS ester is a bifunctional linker featuring a carboxylic acid terminus and a reactive NHS ester, enabling site-specific conjugation to primary amines. The C2-PEG4-C2 spacer provides enhanced solubility and controlled distance between functional groups, facilitating efficient bioconjugation in aqueous environments. This reagent streamlines the synthesis of protein-polymer hybrids and targeted delivery systems.

Application

Acid-C2-PEG4-C2-NHS ester serves as a versatile bifunctional linker for conjugating carboxyl-containing biomolecules to amine-functionalized surfaces or probes. The PEG4 spacer provides enhanced solubility and reduced steric hindrance, while the NHS ester enables efficient coupling under physiological conditions. This reagent facilitates site-specific bioconjugation with excellent stability in aqueous media and is well-suited for antibody-drug conjugate development, protein labeling, and solid-phase synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   147.13
  • LogP   -0.4586
  • H_Acceptors   10
  • H_Donors   1
  • Rotatable_Bonds   19

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