Fmoc-Tyr-OtBu

Name: Fmoc-Tyr-OtBu
Brand: ChemScene
Availability: InStock
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CAS No. 133852-23-0
Cat. No. CS-0154597
Purity≥97%
MDL No.MFCD20264831

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 133852-23-0
Cat. No. CS-0154597
Purity ≥97%
MDL No. MFCD20264831
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₈H₂₉NO₅
Molecular Weight 459.53
Synonym(s) tert-butyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxyphenyl)propanoate
SMILES CC(C)(OC([C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CC4=CC=C(O)C=C4)=O)C

Description

Fmoc-Tyr-OtBu is a protected tyrosine derivative featuring a fluorenylmethoxycarbonyl (Fmoc) group at the N-terminus and a tert-butyl ester at the C-terminus. This configuration enables efficient incorporation into peptide chains during solid-phase synthesis, offering enhanced solubility and stability under standard conditions. The para-hydroxyl group remains available for selective modification or functionalization in downstream applications.

Application

Fmoc-Tyr-OtBu serves as a key building block in peptide synthesis, enabling efficient incorporation of tyrosine residues with orthogonal protection. The Fmoc group allows for mild base-mediated deprotection, while the OtBu ester provides stability during chain elongation and facilitates selective side-chain modification. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for both manual and automated synthesis workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 84.86
LogP 5.1837
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Phenol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-Tyr-OtBu

CAS No. 133852-23-0

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