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CS-W001157 4
Total: USD 88.00

1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride

  • CAS No. 13349-91-2

  • Cat. No. CS-W006273
  • Molecule weight241.08
  • Purity≥97%
  • MDL No.MFCD08261052

*For research and further manufacturing use only, not for direct human use.

1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride|CS-W006273

Structure of 13349-91-2

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General Information

  • CAS No. 13349-91-2
  • Cat. No. CS-W006273
  • Purity ≥97%
  • MDL No. MFCD08261052
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃Cl₂F₃N₂
  • Molecular Weight 241.08
  • Synonym(s) 1-(2,2,2-Trifluoroethyl)piperazine hydrochloride
  • SMILES FC(F)(F)CN1CCNCC1.Cl.Cl

Application

1-(2,2,2-Trifluoroethyl)piperazine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling the introduction of a lipophilic trifluoromethylated ethyl spacer into bioactive molecules. The piperazine core provides a handle for further functionalization, while the dihydrochloride salt enhances solubility and stability for handling. It facilitates access to diverse heterocyclic scaffolds and is compatible with standard coupling and derivatization protocols in API development.

Synthesis

  • Route1

    References

    • WO2004/41829 A1, ; Page 75 ; WO 2004/041829 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   1.2975
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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