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CS-W001157 4
Total: USD 88.00

2,2,2-Trifluoro-1-(piperazin-1-yl)ethanone

  • CAS No. 6511-88-2

  • Cat. No. CS-0205019
  • Purity≥95%
  • MDL No.MFCD07782176

*For research and further manufacturing use only, not for direct human use.

2,2,2-Trifluoro-1-(piperazin-1-yl)ethanone|CS-0205019

Structure of 6511-88-2

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General Information

  • CAS No. 6511-88-2
  • Cat. No. CS-0205019
  • Purity ≥95%
  • MDL No. MFCD07782176
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉F₃N₂O
  • Molecular Weight 182.14
  • Synonym(s) Trifluoroacetylpiperazine
  • SMILES O=C(N1CCNCC1)C(F)(F)F

Description

2,2,2-Trifluoro-1-(piperazin-1-yl)ethanone delivers a potent trifluoromethyl electrophile paired with a piperazine nitrogen for downstream conjugation. This bench-stable ketone integrates readily into bioactive scaffolds, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

2,2,2-Trifluoro-1-(piperazin-1-yl)ethanone serves as a versatile building block for fluorinated pharmacophores, enabling efficient incorporation of trifluoromethyl and piperazinyl moieties into complex scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate direct functionalization in medicinal chemistry campaigns. The molecule functions effectively in amide bond formation and heterocycle synthesis, offering predictable reactivity and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H411
Precautionary Statements : P264-P270-P273-P330-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.34
  • LogP   -0.0195
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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