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CS-W001157 4
Total: USD 88.00

1-Formylpiperazine

  • CAS No. 7755-92-2

  • Cat. No. CS-W016606
  • Molecule weight114.15
  • Purity≥95%
  • MDL No.MFCD00005963

*For research and further manufacturing use only, not for direct human use.

1-Formylpiperazine|CS-W016606

Structure of 7755-92-2

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General Information

  • CAS No. 7755-92-2
  • Cat. No. CS-W016606
  • Purity ≥95%
  • MDL No. MFCD00005963
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀N₂O
  • Molecular Weight 114.15
  • Synonym(s) Piperazine-1-carboxaldehyde; 1-Formylpiperazine
  • SMILES O=CN1CCNCC1

Description

1-Formylpiperazine features a piperazine ring functionalized with a formyl group, delivering enhanced solubility and reactivity in synthetic transformations. This bench-stable derivative serves as a key intermediate in medicinal chemistry, enabling efficient coupling strategies and facilitating the incorporation of polar, nitrogen-rich motifs into complex molecular architectures.

Application

1-Formylpiperazine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds. The formyl group facilitates nucleophilic addition and reductive amination reactions, while the piperazine core provides structural diversity and enhanced solubility. Its bench-stable nature and compatibility with standard purification methods make it well-suited for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      110-85-0
    • null|null
      107-31-3
    • ~69%
    • In-stock
      1-Formylpiperazine|CS-W016606
      7755-92-2

    References

    • Shanghai Institute of Pharmaceutical Industry Patent: US2006/148811 A1, 2006 ; Location in patent: Page/Page column 7 ;
  • Route2
    • null|null
      110-85-0
    • null|null
      201230-82-2
    • ~28%
    • In-stock
      1-Formylpiperazine|CS-W016606
      7755-92-2
    • In-stock
      1,4-Diformylpiperazine|CS-0155228
      4164-39-0

    References

    • Journal of Organometallic Chemistry, , vol. 368, p. 103 - 110
  • Route3
    • null|null
      110-85-0
    • null|null
      68-12-2
    • ~77%
    • In-stock
      1-Formylpiperazine|CS-W016606
      7755-92-2

    References

    • Yang, Dongsik; Jeon, Heung Bae Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 5 p. 1424 - 1426

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.34
  • LogP   -0.952
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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