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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(2,2,2-Trifluoroacetyl)piperazine-1-carboxylate

  • CAS No. 77278-37-6

  • Cat. No. CS-W001641
  • Purity≥95%
  • MDL No.MFCD22421755

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(2,2,2-Trifluoroacetyl)piperazine-1-carboxylate|CS-W001641

Structure of 77278-37-6

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General Information

  • CAS No. 77278-37-6
  • Cat. No. CS-W001641
  • Purity ≥95%
  • MDL No. MFCD22421755
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇F₃N₂O₃
  • Molecular Weight 282.26
  • Synonym(s) 1-Piperazinecarboxylic acid, 4-(trifluoroacetyl)-, 1,1-dimethylethyl ester
  • SMILES O=C(N1CCN(CC1)C(=O)C(F)(F)F)OC(C)(C)C

Synthesis

  • Route1
    • null|null
      407-25-0
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~10%
    • tert-Butyl 4-(2,2,2-Trifluoroacetyl)piperazine-1-carboxylate|CS-W001641
      77278-37-6

    References

    • F.HOFFMANN-LA ROCHE AG Patent: WO2005/110996 A1, 2005 ; Location in patent: Page/Page column 45-46 ;
  • Route2
    • null|null
      383-63-1
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~%
    • tert-Butyl 4-(2,2,2-Trifluoroacetyl)piperazine-1-carboxylate|CS-W001641
      77278-37-6

    References

    • ICI Americas Inc. Patent: US4247549 A1, 1981 ;
  • Route3
    • null|null
      354-32-5
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~%
    • tert-Butyl 4-(2,2,2-Trifluoroacetyl)piperazine-1-carboxylate|CS-W001641
      77278-37-6

    References

    • Zulli, Allison L.; Aimone, Lisa D.; Mathiasen, Joanne R.; Gruner, John A.; Raddatz, Rita; Bacon, Edward R.; Hudkins, Robert L. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2807 - 2810

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.85
  • LogP   1.628
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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