Lot numbers can be found on the outside label of a product:
4-Methylbenzoic anhydride
-
CAS No. 13222-85-0
- Cat. No. CS-W022217
- Purity≥95%
- MDL No.MFCD00048100
*For research and further manufacturing use only, not for direct human use.
Structure of 13222-85-0
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 13222-85-0
- Cat. No. CS-W022217
- Purity ≥95%
- MDL No. MFCD00048100
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₆H₁₄O₃
- Molecular Weight 254.28
- Synonym(s) P-TOLUIC ANHYDRIDE
- SMILES O=C(OC(C1=CC=C(C)C=C1)=O)C2=CC=C(C)C=C2
Description
4-Methylbenzoic anhydride delivers a reactive acylating moiety for efficient amide bond formation. The para-methyl group enhances electron density at the carbonyl, improving reactivity while maintaining bench-stable handling. This anhydride integrates readily into synthetic workflows requiring selective derivatization of amines and alcohols under mild conditions.
Application
4-Methylbenzoic anhydride serves as a versatile acylating agent in synthetic organic chemistry, enabling efficient ester and amide formation under mild conditions. Its benzylic methyl group enhances stability and facilitates purification, while the aromatic anhydride core exhibits high reactivity toward nucleophiles. This reagent functions reliably in standard bench-scale transformations, including peptide coupling and heterocycle functionalization, offering predictable yields and minimal side reactions.
Synthesis
-
Route1
-
874-60-2 - ~98%
-
In-stock
13222-85-0
References
-
Hu, Yulai; Wang, Jin-Xian; Li, Shihua Synthetic Communications, 1997 , vol. 27, # 2 p. 243 - 248
-
-
Route2
-
874-60-2
-
In-stock
99-94-5 - ~93%
-
In-stock
13222-85-0
References
-
Fife, Wilmer K.; Zhang, Zhi-dong Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4933 - 4936
-
-
Route3
-
201230-82-2
-
In-stock
624-31-7 - ~95%
-
In-stock
13222-85-0
References
-
Li, Yang; Xue, Dong; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Chemical Communications, 2012 , vol. 48, # 9 p. 1320 - 1322
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 43.37
- LogP 3.30064
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4-Methylbenzoic anhydride sigma4-Methylbenzoic anhydride manufacturer4-Methylbenzoic anhydride price4-Methylbenzoic anhydride structure4-Methylbenzoic anhydride SDSbuy 4-Methylbenzoic anhydride4-Methylbenzoic anhydride supplier4-Methylbenzoic anhydride uses4-Methylbenzoic anhydride molecular weightprice of 4-Methylbenzoic anhydride4-Methylbenzoic anhydride chemical name formula of 4-Methylbenzoic anhydride