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CS-W001157 4
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p-Toluic acid

  • CAS No. 99-94-5

  • Cat. No. CS-D0602
  • Purity≥97%
  • MDL No.MFCD00002565

*For research and further manufacturing use only, not for direct human use.

p-Toluic acid|CS-D0602

Structure of 99-94-5

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General Information

  • CAS No. 99-94-5
  • Cat. No. CS-D0602
  • Purity ≥97%
  • MDL No. MFCD00002565
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₂
  • Molecular Weight 136.15
  • Synonym(s) 4-Methylbenzoic acid
  • SMILES O=C(O)C(C=C1)=CC=C1C

Description

Pomalidomide-propargyl contains an E3 ligand and a terminal alkyl group ready for click conjugation. This product is ready for conjugation to target proteins for PROTAC R&D.

Application

p-Toluic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aromatic systems. Its well-established reactivity facilitates direct esterification, amidation, and coupling reactions under standard conditions. The methyl group provides a handle for selective oxidation or further functionalization, while the carboxylic acid moiety offers robust compatibility with common protection and activation protocols. This stability and predictable behavior make p-Toluic acid a reliable scaffold for pharmaceutical intermediates and specialty materials synthesis.

Synthesis

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    • In-stock
      p-Toluic acid|CS-D0602
      99-94-5

    References

    • Journal of the Chemical Society, , vol. 95, p. 969
  • Route2

    References

    • Chemische Berichte, , vol. 5, p. 267
  • Route3

    References

    • Bulletin of the Chemical Society of Japan, , vol. 16, p. 252,258 Bulletin of the Chemical Society of Japan, , vol. 18, p. 200

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.69322
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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