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CS-W001157 4
Total: USD 88.00

4-Fluorobenzoic anhydride

  • CAS No. 25569-77-1

  • Cat. No. CS-W022182
  • Purity≥96%
  • MDL No.MFCD00425938

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzoic anhydride|CS-W022182

Structure of 25569-77-1

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General Information

  • CAS No. 25569-77-1
  • Cat. No. CS-W022182
  • Purity ≥96%
  • MDL No. MFCD00425938
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₈F₂O₃
  • Molecular Weight None
  • Synonym(s) p-Fluorobenzoic anhydride
  • SMILES FC1=CC=C(C=C1)C(=O)OC(=O)C1=CC=C(F)C=C1

Description

4-Fluorobenzoic anhydride delivers a reactive acylating agent with enhanced electrophilicity due to the electron-withdrawing fluorine substituent. This bench-stable derivative enables efficient amide and ester formation under mild conditions, offering high functional group tolerance for synthetic applications in medicinal chemistry and materials science.

Application

4-Fluorobenzoic anhydride serves as a highly effective acylating agent for the installation of fluorinated benzoyl groups under mild conditions. It facilitates efficient amide and ester formation with broad functional group tolerance, enabling straightforward derivatization of amines and alcohols. Its bench-stable solid form and clean reaction profiles simplify purification and scale-up, making it a practical choice for synthetic intermediates in medicinal chemistry and materials science workflows.

Synthesis

  • Route1
    • In-stock
      4-Iodofluorobenzene|CS-D1411
      352-34-1
    • null|null
      201230-82-2
    • ~98%
    • In-stock
      4-Fluorobenzoic anhydride|CS-W022182
      25569-77-1

    References

    • Li, Yang; Xue, Dong; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Chemical Communications, 2012 , vol. 48, # 9 p. 1320 - 1322
  • Route2

    References

    • Hu, Yu Lin; Zhao, Xing E.; Lu, Ming Bulletin of the Chemical Society of Ethiopia, 2011 , vol. 25, # 2 p. 255 - 262
  • Route3

    References

    • Cirriez, Virginie; Rasson, Corentin; Riant, Olivier Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3137 - 3140

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   2.962
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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