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3-Fluoro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

  • CAS No. 1310384-35-0

  • Cat. No. CS-0173727
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine|CS-0173727

Structure of 1310384-35-0

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General Information

  • CAS No. 1310384-35-0
  • Cat. No. CS-0173727
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇BFNO₃
  • Molecular Weight 253.08
  • Synonym(s) 5-Fluoro-6-methoxypyridine-3-boronic acid pinacol ester
  • SMILES CC1(C)C(C)(C)OB(C2=CN=C(OC)C(F)=C2)O1

Description

This boronate ester features a 3-fluoro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine scaffold, combining electron-deficient pyridine reactivity with a stable, moisture-tolerant boronate handle. The para-substituted dioxaborolane integrates readily into Suzuki-Miyaura cross-coupling reactions under mild conditions, enabling efficient C–C bond formation in complex molecular architectures.

Application

3-Fluoro-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine serves as a versatile Suzuki-Miyaura coupling partner, enabling efficient C–C bond formation under mild conditions. The boronate ester group exhibits excellent stability and compatibility with diverse functional groups, while the fluorine and methoxy substituents provide orthogonal reactivity for downstream modifications. Its bench-stable nature and predictable coupling efficiency make it ideal for constructing complex heterocyclic architectures in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.58
  • LogP   1.5285
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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