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CS-W001157 4
Total: USD 88.00

(5-Methylpyridin-2-yl)boronic acid

  • CAS No. 372963-49-0

  • Cat. No. CS-W018321
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Methylpyridin-2-yl)boronic acid|CS-W018321

Structure of 372963-49-0

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General Information

  • CAS No. 372963-49-0
  • Cat. No. CS-W018321
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈BNO₂
  • Molecular Weight 136.95
  • Synonym(s) 5-Methylpyridine-2-boronic acid
  • SMILES CC1=CN=C(B(O)O)C=C1

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, offering enhanced stability and solubility in polar aprotic solvents. The methyl group at the 5-position provides steric and electronic tuning, improving reaction efficiency while maintaining bench-stable handling.

Application

(5-Methylpyridin-2-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient C–C bond formation under palladium catalysis. Its pyridine core offers enhanced solubility and stability compared to simpler aryl boronic acids, while the methyl group provides mild electronic activation. The compound exhibits excellent functional group tolerance and is readily purified by recrystallization, making it ideal for constructing biologically relevant heterocyclic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.93018
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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