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CS-W001157 4
Total: USD 88.00

(5-Fluoro-6-methoxypyridin-3-yl)boronic acid

  • CAS No. 856250-60-7

  • Cat. No. CS-0150568
  • Purity≥97%
  • MDL No.MFCD04112520

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-6-methoxypyridin-3-yl)boronic acid|CS-0150568

Structure of 856250-60-7

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General Information

  • CAS No. 856250-60-7
  • Cat. No. CS-0150568
  • Purity ≥97%
  • MDL No. MFCD04112520
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BFNO₃
  • Molecular Weight 170.93
  • Synonym(s) 5-Fluoro-6-methoxypyridine-3-boronic acid
  • SMILES COC1=C(C=C(C=N1)B(O)O)F

Description

This boronate moiety features a fluorinated pyridine core with a methoxy group at the 6-position, delivering enhanced stability and solubility in polar solvents. The electron-deficient heterocycle enables efficient Suzuki-Miyaura coupling under standard conditions, facilitating rapid access to functionalized biaryl scaffolds for medicinal chemistry applications.

Application

(5-Fluoro-6-methoxypyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The fluorine and methoxy groups provide orthogonal reactivity and enhanced stability, while the boronic acid functionality facilitates reliable coupling under mild conditions. This compound exhibits excellent bench stability and is readily purified by standard methods, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -1.0909
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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