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Structure of 1303974-47-1
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tert-Butyl 3,3-difluoro-4-(hydroxymethyl)piperidine-1-carboxylate is a bench-stable, moisture-tolerant piperidine derivative featuring a sterically hindered tert-butyl ester and a reactive hydroxymethyl group. The geminal difluoride moiety imparts enhanced metabolic stability and modulates electronic properties. This compound serves as a key building block for fluorinated bioactive molecules, enabling direct functionalization in late-stage synthesis.
tert-Butyl 3,3-difluoro-4-(hydroxymethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the introduction of a difluorinated piperidine scaffold with a pendant hydroxymethyl group. The tert-butyl carbamate protects the amine under standard conditions, while the hydroxymethyl functionality offers a handle for further derivatization via oxidation, etherification, or coupling reactions. Its bench-stable nature and compatibility with diverse reaction conditions support efficient synthesis of complex heterocyclic architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: