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CS-W001157 4
Total: USD 88.00

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride

  • CAS No. 1783945-29-8

  • Cat. No. CS-0053392
  • Purity≥98%
  • MDL No.MFCD27978586
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride|CS-0053392

Structure of 1783945-29-8

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Description

This bench-stable, moisture-tolerant building block features a difluorinated piperidine core that enhances metabolic stability and membrane permeability. The hydrochloride salt form ensures excellent solubility in aqueous and polar organic media, facilitating seamless integration into synthetic workflows for medicinal chemistry and drug discovery applications.

Application

(3,3-Difluoropiperidin-4-yl)methanol hydrochloride serves as a valuable building block in medicinal chemistry, enabling the introduction of a difluorinated piperidine motif with enhanced metabolic stability and modulated basicity. The hydrochloride salt ensures excellent bench stability and solubility, facilitating straightforward handling and purification. It functions as a key intermediate in the synthesis of bioactive heterocycles, particularly in projects requiring constrained, fluorinated scaffolds for improved pharmacokinetic profiles.

General Information

  • CAS No. 1783945-29-8
  • Cat. No. CS-0053392
  • Purity ≥98%
  • MDL No. MFCD27978586
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClF₂NO
  • Molecular Weight 187.62
  • Synonym(s) None
  • SMILES OCC1CCNCC1(F)F.Cl

Computational Chemistry Data

  • TPSA   32.26
  • LogP   0.6453
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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