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CS-W001157 4
Total: USD 88.00

1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid

  • CAS No. 1303972-81-7

  • Cat. No. CS-W001386
  • Molecule weight265.26
  • Purity≥97%
  • MDL No.MFCD18909780

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid|CS-W001386

Structure of 1303972-81-7

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General Information

  • CAS No. 1303972-81-7
  • Cat. No. CS-W001386
  • Purity ≥97%
  • MDL No. MFCD18909780
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇F₂NO₄
  • Molecular Weight 265.26
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(C(=O)O)C(F)(F)C1

Description

This difluorinated piperidine derivative features a tert-butyl carbamate-protected amine and a carboxylic acid group, enabling direct incorporation into peptide backbones. The fluorinated ring imparts enhanced metabolic stability and modulates electronic properties for optimized binding affinity in bioactive molecule design.

Application

1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a sterically constrained, electron-deficient piperidine motif with enhanced metabolic stability. The difluoro substitution at C3 enhances lipophilicity and modulates basicity, while the Boc-protected carboxylic acid facilitates straightforward coupling reactions and orthogonal deprotection. Its bench-stable nature and compatibility with standard peptide synthesis protocols make it ideal for constructing bioactive heterocyclic scaffolds in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.9633
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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