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CS-W001157 4
Total: USD 88.00

1-(Boc)-3-Fluoropiperidine-4-carboxylic acid

  • CAS No. 1303974-46-0

  • Cat. No. CS-W001393
  • Purity≥95%
  • MDL No.MFCD18909772

*For research and further manufacturing use only, not for direct human use.

1-(Boc)-3-Fluoropiperidine-4-carboxylic acid|CS-W001393

Structure of 1303974-46-0

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General Information

  • CAS No. 1303974-46-0
  • Cat. No. CS-W001393
  • Purity ≥95%
  • MDL No. MFCD18909772
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈FNO₄
  • Molecular Weight 247.27
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(C(=O)O)C(F)C1

Description

1-(Boc)-3-Fluoropiperidine-4-carboxylic acid features a fluorinated piperidine core with a Boc-protected carboxylic acid, enabling stable incorporation into peptide and small-molecule scaffolds. The electron-withdrawing fluorine enhances metabolic stability and modulates conformational flexibility. This derivative facilitates efficient synthesis of bioactive compounds under standard conditions.

Application

1-(Boc)-3-fluoropiperidine-4-carboxylic acid serves as a versatile building block for the synthesis of fluorinated piperidine-containing scaffolds prevalent in medicinal chemistry. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the carboxylic acid functionality enables direct coupling reactions or derivatization. This compound exhibits robust bench stability and functional group tolerance, facilitating efficient incorporation into complex molecular architectures through standard peptide coupling and reductive amination protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.6661
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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