Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-3-nitropyrazine

  • CAS No. 87885-43-6

  • Cat. No. CS-W005840
  • Molecule weight159.53
  • Purity≥97%
  • MDL No.MFCD10697796

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-nitropyrazine|CS-W005840

Structure of 87885-43-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 87885-43-6
  • Cat. No. CS-W005840
  • Purity ≥97%
  • MDL No. MFCD10697796
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂ClN₃O₂
  • Molecular Weight 159.53
  • Synonym(s) 2-chloro-3-nitro-pyrazine
  • SMILES O=[N+](C1=NC=CN=C1Cl)[O-]

Description

2-Chloro-3-nitropyrazine is a heterocyclic building block featuring a chloro group at the 2-position and a nitro group at the 3-position on the pyrazine ring. This electron-deficient scaffold enables selective cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive molecules, particularly in medicinal chemistry and agrochemical development.

Application

2-Chloro-3-nitropyrazine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloro substituent. The nitro group enhances electrophilicity at the pyrazine ring, facilitating nucleophilic substitution and serving as a handle for downstream reduction to an amine. Its bench-stable crystalline form and compatibility with standard synthetic protocols make it ideal for constructing complex nitrogen-containing scaffolds relevant to medicinal chemistry and agrochemical development.

Synthesis

  • Route1
    • null|null
      86536-74-5
    • ~%
    • In-stock
      2-Chloro-3-nitropyrazine|CS-W005840
      87885-43-6

    References

    • Journal of Heterocyclic Chemistry, , vol. 20, # 4 p. 947 - 950
  • Route2

    References

    • Merck and Co., Inc. Patent: US4709035 A1, 1987 ;
  • Route3
    • null|null
      105410-36-4
    • ~%
    • In-stock
      2-Chloro-3-nitropyrazine|CS-W005840
      87885-43-6

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 12 p. 1634 - 1639

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   68.92
  • LogP   1.0382
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Chloro-3-nitropyrazine sigma2-Chloro-3-nitropyrazine manufacturer2-Chloro-3-nitropyrazine price2-Chloro-3-nitropyrazine structure2-Chloro-3-nitropyrazine SDSbuy 2-Chloro-3-nitropyrazine2-Chloro-3-nitropyrazine supplier2-Chloro-3-nitropyrazine uses2-Chloro-3-nitropyrazine molecular weightprice of 2-Chloro-3-nitropyrazine2-Chloro-3-nitropyrazine chemical name formula of 2-Chloro-3-nitropyrazine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label