2-Chloro-3-nitropyrazine

Name: 2-Chloro-3-nitropyrazine
Brand: ChemScene
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CAS No. 87885-43-6
Cat. No. CS-W005840
Purity≥97%
MDL No.MFCD10697796

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

2-Chloro-3-nitropyrazine is a heterocyclic building block featuring a chloro group at the 2-position and a nitro group at the 3-position on the pyrazine ring. This electron-deficient scaffold enables selective cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive molecules, particularly in medicinal chemistry and agrochemical development.

Application

2-Chloro-3-nitropyrazine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloro substituent. The nitro group enhances electrophilicity at the pyrazine ring, facilitating nucleophilic substitution and serving as a handle for downstream reduction to an amine. Its bench-stable crystalline form and compatibility with standard synthetic protocols make it ideal for constructing complex nitrogen-containing scaffolds relevant to medicinal chemistry and agrochemical development.

General Information

CAS No. 87885-43-6
Cat. No. CS-W005840
Purity ≥97%
MDL No. MFCD10697796
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂ClN₃O₂
Molecular Weight 159.53
Synonym(s) 2-chloro-3-nitro-pyrazine
SMILES O=[N+](C1=NC=CN=C1Cl)[O-]

Computational Chemistry Data

TPSA 68.92
LogP 1.0382
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2-Chloro-3-nitropyrazine

CAS No. 87885-43-6

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