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CS-W001157 4
Total: USD 88.00

4-Chloro-2-methoxy-3-nitropyridine

  • CAS No. 934180-48-0

  • Cat. No. CS-0145999
  • Purity≥98%
  • MDL No.MFCD17014990

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-methoxy-3-nitropyridine|CS-0145999

Structure of 934180-48-0

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General Information

  • CAS No. 934180-48-0
  • Cat. No. CS-0145999
  • Purity ≥98%
  • MDL No. MFCD17014990
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₃
  • Molecular Weight 188.57
  • Synonym(s) None
  • SMILES O=[N+](C1=C(Cl)C=CN=C1OC)[O-]

Description

4-Chloro-2-methoxy-3-nitropyridine is a nitropyridine derivative featuring orthogonal reactivity at the chloro and nitro positions. This electron-deficient heterocycle integrates readily into cross-coupling cascades and serves as a key intermediate in the synthesis of bioactive pyridine-based scaffolds, offering predictable regioselectivity under standard conditions.

Application

4-Chloro-2-methoxy-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The methoxy and nitro groups provide orthogonal functional handles for sequential transformations, while the compound exhibits good bench stability and facilitates efficient purification. Its reactivity profile supports the synthesis of complex heterocyclic scaffolds commonly found in pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.26
  • LogP   1.6518
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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