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Structure of 128886-88-4
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This trifluoromethyl-substituted diazirine aldehyde integrates a photoreactive diazirine ring with an electron-deficient aromatic system, enabling site-specific protein crosslinking upon UV irradiation. The para-aldelyde functionality supports direct conjugation to biomolecules via reductive amination or hydrazone formation, while the trifluoromethyl group enhances metabolic stability and modulates electronic properties for efficient photoactivation.
4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzaldehyde serves as a versatile photoreactive building block for covalent labeling and cross-linking applications. The trifluoromethyl-substituted diazirine ring enables efficient photoactivation under UV light, facilitating irreversible attachment to proximal biomolecules. The aldehyde functionality provides a site for conjugation via reductive amination or hydrazone formation, enabling site-specific probe integration. Its bench-stable nature and compatibility with diverse functional groups make it suitable for synthetic workflows in chemical biology and target identification.
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GHS No : GHS02,GHS05
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Signal Word : Danger
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UN#: 2924
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Class : 3,8
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Packing Group : Ⅱ
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Hazard Statements : H226-H314
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Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501
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Lot numbers can be found on the outside label of a product: