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CS-W001157 4
Total: USD 88.00

(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanol

  • CAS No. 87736-88-7

  • Cat. No. CS-0008638
  • Purity≥96%
  • MDL No.MFCD19442582

*For research and further manufacturing use only, not for direct human use.

(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanol|CS-0008638

Structure of 87736-88-7

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General Information

  • CAS No. 87736-88-7
  • Cat. No. CS-0008638
  • Purity ≥96%
  • MDL No. MFCD19442582
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃N₂O
  • Molecular Weight None
  • Synonym(s) 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Alcohol
  • SMILES OCC1=CC=C(C2(C(F)(F)F)N=N2)C=C1

Application

(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanol serves as a versatile photoreactive building block for covalent labeling studies. The trifluoromethyl-substituted diazirine moiety enables efficient UV-induced formation of reactive carbene intermediates, facilitating site-specific protein and biomolecule cross-linking. The benzyl alcohol functionality provides a handle for conjugation or further derivatization. Exhibiting good bench stability and compatibility with common organic solvents, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      87736-86-5
    • ~93%
    • In-stock
      (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanol|CS-0008638
      87736-88-7

    References

    • Liebigs Annalen der Chemie, , # 9 p. 1510 - 1523
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 16 p. 4818 - 4825
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 128, # 47 p. 15092 - 15093

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   44.95
  • LogP   2.3598
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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