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CS-W001157 4
Total: USD 88.00

3-Phenyl-3-(trifluoromethyl)-3H-diazirine

  • CAS No. 73899-14-6

  • Cat. No. CS-0008636
  • Purity≥95%
  • MDL No.MFCD22041649

*For research and further manufacturing use only, not for direct human use.

3-Phenyl-3-(trifluoromethyl)-3H-diazirine|CS-0008636

Structure of 73899-14-6

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General Information

  • CAS No. 73899-14-6
  • Cat. No. CS-0008636
  • Purity ≥95%
  • MDL No. MFCD22041649
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃N₂
  • Molecular Weight 186.13
  • Synonym(s) 3-phenyl-3-(trifluoromethyl)diazirine
  • SMILES FC(C1(C2=CC=CC=C2)N=N1)(F)F

Description

3-Phenyl-3-(trifluoromethyl)-3H-diazirine is a bench-stable, moisture-tolerant photoaffinity label featuring a highly reactive diazirine ring. This trifluoromethyl-substituted aryl diazirine integrates readily into bioconjugation workflows, enabling site-specific protein crosslinking upon UV irradiation. The electron-withdrawing trifluoromethyl group enhances photolysis efficiency while stabilizing the carbene intermediate formed during activation.

Application

3-Phenyl-3-(trifluoromethyl)-3H-diazirine serves as a stable, bench-compatible photoaffinity labeling agent, enabling site-specific covalent capture of interacting biomolecules upon UV irradiation. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the diazirine ring undergoes efficient photolysis to generate reactive carbene intermediates. This compound facilitates targeted protein-ligand interaction studies and is compatible with diverse biological matrices and downstream analytical workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅱ
Hazard Statements : H226-H314-H318
Precautionary Statements : P210-P240-P242-P243-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P501

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Computational Chemistry Data

  • TPSA   24.72
  • LogP   2.8675
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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