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CS-W001157 4
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1-(3-Amino-2-fluorophenyl)ethanone

  • CAS No. 1262098-06-5

  • Cat. No. CS-0186236
  • Molecule weight153.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Amino-2-fluorophenyl)ethanone|CS-0186236

Structure of 1262098-06-5

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General Information

  • CAS No. 1262098-06-5
  • Cat. No. CS-0186236
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO
  • Molecular Weight 153.15
  • Synonym(s) 1-(3-Amino-2-fluoro-phenyl)-ethanone
  • SMILES CC(=O)C1=C(C(=CC=C1)N)F

Description

1-(3-Amino-2-fluorophenyl)ethanone features a strategically positioned amino group flanked by fluorine and ketone functionalities, enabling direct incorporation into bioactive scaffolds. This electron-rich aryl ketone serves as a key intermediate in the synthesis of pharmaceuticals and functionalized heterocycles, offering enhanced reactivity under standard coupling conditions.

Application

1-(3-Amino-2-fluorophenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aryl ketones and heterocyclic scaffolds. Its amino and fluoro substituents offer orthogonal reactivity for coupling, cyclization, and functionalization reactions. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.6105
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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