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CS-W001157 4
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6-Bromo-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid

  • CAS No. 1260386-47-7

  • Cat. No. CS-0050309
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid|CS-0050309

Structure of 1260386-47-7

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General Information

  • CAS No. 1260386-47-7
  • Cat. No. CS-0050309
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) None
  • SMILES OC(=O)C1=CC2=NC=C(Br)C=C2N1

Description

6-Bromo-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid features a brominated pyrrolopyridine core with a carboxylic acid group at the 2-position, enabling direct coupling in late-stage functionalization. This electron-deficient heterocycle integrates readily into medicinal chemistry libraries and serves as a key scaffold for kinase inhibitors and targeted covalent agents.

Application

6-Bromo-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles, enabling direct functionalization at the brominated position via Pd-catalyzed cross-coupling. The carboxylic acid group provides a handle for derivatization and facilitates purification through salt formation or chromatography. Its stability under standard bench conditions and compatibility with diverse reaction environments make it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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