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tert-Butyl N-[[(3R)-morpholin-3-yl]methyl]carbamate

  • CAS No. 1257850-83-1

  • Cat. No. CS-0060994
  • Molecule weight216.28
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[[(3R)-morpholin-3-yl]methyl]carbamate|CS-0060994

Structure of 1257850-83-1

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General Information

  • CAS No. 1257850-83-1
  • Cat. No. CS-0060994
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) (R)-tert-Butyl (morpholin-3-ylmethyl)carbamate
  • SMILES CC(C)(OC(NC[C@@H]1COCCN1)=O)C

Description

tert-Butyl N-[[(3R)-morpholin-3-yl]methyl]carbamate features a chiral morpholine moiety that delivers enhanced solubility and metabolic stability in peptide synthesis. This bench-stable carbamate serves as a protected amine handle, integrating seamlessly into complex molecular architectures under standard conditions.

Application

tert-Butyl N-[[(3R)-morpholin-3-yl]methyl]carbamate serves as a stable, bench-friendly building block for the synthesis of chiral morpholine-containing scaffolds. The (3R)-configured morpholinomethyl group enables stereoselective transformations in medicinal chemistry, while the tert-butyl carbamate protects primary amines under standard reaction conditions. Its compatibility with hydrogenation, nucleophilic substitution, and coupling reactions facilitates efficient access to complex heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.59
  • LogP   0.4995
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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