tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate

Name: tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate
Brand: ChemScene
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CAS No. 1187929-33-4
Cat. No. CS-0060964
Purity≥97%
MDL No.MFCD06739119

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate|CS-0060964

Structure of 1187929-33-4

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Description

tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate is a chiral, bench-stable building block featuring a morpholine core with a protected amine and a tert-butyl ester. This configuration enables selective incorporation into peptidomimetics and bioactive scaffolds, where the aminomethyl group serves as a versatile handle for further functionalization.

Application

tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of morpholine-containing scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating sequential transformations. Its bench-stable tert-butyl ester and stereogenic center support efficient route design with high enantiomeric purity, making it ideal for modular peptide-like and heterocyclic compound assembly.

General Information

CAS No. 1187929-33-4
Cat. No. CS-0060964
Purity ≥97%
MDL No. MFCD06739119
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₃
Molecular Weight 216.28
Synonym(s) (R)-tert-Butyl 3-(aminomethyl)morpholine-4-carboxylate
SMILES O=C(N1[C@H](CN)COCC1)OC(C)(C)C

Computational Chemistry Data

TPSA 64.79
LogP 0.581
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (R)-3-(aminomethyl)morpholine-4-carboxylate

CAS No. 1187929-33-4

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