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tert-Butyl (S)-3-(aminomethyl)morpholine-4-carboxylate

  • CAS No. 1187929-79-8

  • Cat. No. CS-0060962
  • Molecule weight216.28
  • Purity≥97%
  • MDL No.MFCD06796250

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (S)-3-(aminomethyl)morpholine-4-carboxylate|CS-0060962

Structure of 1187929-79-8

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General Information

  • CAS No. 1187929-79-8
  • Cat. No. CS-0060962
  • Purity ≥97%
  • MDL No. MFCD06796250
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) tert-Butyl-(3S)-3-(aminomethyl)morpholin-4-carboxylat
  • SMILES O=C(N1[C@@H](CN)COCC1)OC(C)(C)C

Description

tert-Butyl (S)-3-(aminomethyl)morpholine-4-carboxylate is a chiral, bench-stable building block featuring a morpholine scaffold with a protected amine and a tert-butyl ester. This configuration enables direct incorporation into peptide-like scaffolds and bioactive molecule synthesis, offering enhanced solubility and compatibility in aqueous/organic media during multi-step transformations.

Application

tert-Butyl (S)-3-(aminomethyl)morpholine-4-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of morpholine-containing scaffolds via standard deprotection and functionalization protocols. The tert-butyl ester provides bench stability and facile removal under mild acidic conditions, while the (S)-configured morpholine ring offers defined stereochemistry for targeted molecular design. Its amine functionality facilitates conjugation reactions and further derivatization, supporting applications in API development and fragment-based lead discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.79
  • LogP   0.581
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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