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(4R,4'R)-2,2'-Cyclobutylidenebis[4,5-dihydro-4-phenyloxazole]

  • CAS No. 1246401-48-8

  • Cat. No. CS-0104007
  • Molecule weight346.42
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4R,4'R)-2,2'-Cyclobutylidenebis[4,5-dihydro-4-phenyloxazole]|CS-0104007

Structure of 1246401-48-8

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General Information

  • CAS No. 1246401-48-8
  • Cat. No. CS-0104007
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₂N₂O₂
  • Molecular Weight 346.42
  • Synonym(s) (4R,4'R)-2,2'-(Cyclobutane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole)
  • SMILES [C@@H]1(C2=CC=CC=C2)COC(C3(CCC3)C4=N[C@H](C5=CC=CC=C5)CO4)=N1

Description

This chiral bis-oxazole features a rigid cyclobutylidene bridge that enforces defined spatial orientation, enabling precise molecular recognition. The 4,5-dihydro-4-phenyloxazole moieties deliver enhanced stability and solubility in polar organic media. Designed for asymmetric synthesis, it serves as a robust scaffold in catalyst design and ligand development.

Application

(4R,4'R)-2,2'-Cyclobutylidenebis[4,5-dihydro-4-phenyloxazole] serves as a chiral bis-oxazole scaffold with defined stereochemistry, enabling asymmetric synthesis in catalytic systems. Its rigid cyclobutylidene bridge imparts conformational control, while the dihydrooxazole rings offer stable, functional group-tolerant platforms for transition metal coordination and ligand development. The compound exhibits bench stability and facilitates modular derivatization in synthetic routes requiring stereocontrolled heterocyclic frameworks.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   4.4967
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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