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CS-W001157 4
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(4R,4'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4-phenyloxazole]

  • CAS No. 1819994-24-5

  • Cat. No. CS-0103896
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4R,4'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4-phenyloxazole]|CS-0103896

Structure of 1819994-24-5

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General Information

  • CAS No. 1819994-24-5
  • Cat. No. CS-0103896
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₀N₂O₂
  • Molecular Weight 332.40
  • Synonym(s) (4R,4'R)-2,2'-(cyclopropane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole)
  • SMILES C1(C2(C3=N[C@H](C4=CC=CC=C4)CO3)CC2)=N[C@H](C5=CC=CC=C5)CO1

Description

This chiral bis-oxazole scaffold features a rigid cyclopropylidene bridge linking two dihydro-4-phenyloxazole units, delivering high stereochemical integrity. The structure combines electron-rich aromatic systems with defined spatial orientation, enabling precise molecular recognition in asymmetric synthesis and supramolecular applications.

Application

(4R,4'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4-phenyloxazole] serves as a chiral bis-oxazole scaffold with defined stereochemistry, enabling asymmetric synthesis in medicinal chemistry. Its rigid cyclopropylidene bridge enhances conformational stability and facilitates predictable spatial orientation in transition metal-catalyzed coupling reactions. The dihydro-oxazole rings exhibit good bench stability and tolerate a range of functional groups, simplifying purification and integration into complex molecular architectures. Functions effectively as a ligand precursor or building block for heterocyclic APIs requiring controlled stereochemistry and structural rigidity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   4.1066
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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