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5-Chloro-2-(chloromethyl)pyridine hydrochloride

  • CAS No. 124425-84-9

  • Cat. No. CS-0498648
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-(chloromethyl)pyridine hydrochloride|CS-0498648

Structure of 124425-84-9

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General Information

  • CAS No. 124425-84-9
  • Cat. No. CS-0498648
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆Cl₃N
  • Molecular Weight 198.48
  • Synonym(s) Pyridine, 5-chloro-2-(chloroMethyl)-, hydrochloride
  • SMILES ClCC1=NC=C(C=C1)Cl.[H]Cl

Description

5-Chloro-2-(chloromethyl)pyridine hydrochloride features a chloromethyl group at the pyridine 2-position, enabling direct functionalization in synthetic workflows. The electron-deficient heterocycle facilitates nucleophilic substitution reactions under mild conditions. This bench-stable salt form enhances handling and solubility in polar media, streamlining integration into multi-step syntheses.

Application

5-Chloro-2-(chloromethyl)pyridine hydrochloride serves as a versatile bifunctional building block for medicinal chemistry and process development. The chloromethyl group enables efficient alkylation reactions, while the pyridyl chloride facilitates palladium-catalyzed cross-couplings. Its stability under standard bench conditions and ease of purification make it well-suited for constructing complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8956
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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