Fmoc-β-HoGlu(OtBu)-OH

Name: Fmoc-β-HoGlu(OtBu)-OH
Brand: ChemScene
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CAS No. 203854-49-3
Cat. No. CS-W011604
Purity≥97%
MDL No.MFCD01863053

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 203854-49-3

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General Information

CAS No. 203854-49-3
Cat. No. CS-W011604
Purity ≥97%
MDL No. MFCD01863053
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₉NO₆
Molecular Weight 439.50
Synonym(s) None
SMILES CC(C)(OC(CC[C@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC(O)=O)=O)C

Description

Fmoc-β-HoGlu(OtBu)-OH is a protected amino acid derivative featuring a β-hydroxyglutamic acid scaffold with orthogonal side-chain protection. This variant enables selective conjugation in peptide synthesis, where the hydroxyl group remains available for downstream modifications. The Fmoc group ensures efficient stepwise coupling under standard conditions, while the OtBu ester provides stability during purification and handling.

Application

Fmoc-β-HoGlu(OtBu)-OH serves as a key building block for the synthesis of peptide conjugates and cyclic peptides, leveraging the orthogonal reactivity of its Fmoc group and stable OtBu ester. Its β-hydroxyglutamic acid scaffold enables precise incorporation of hydroxyl functionality into peptide backbones, facilitating downstream derivatization or structural modulation. The compound exhibits excellent bench stability, simplifies purification via standard chromatographic methods, and is compatible with established solid-phase peptide synthesis protocols.

Synthesis

Route1
- 203854-39-1
- ~82%
- In-stock
  
  203854-49-3
References
- Ananda; Suresh Babu Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 4 p. 418 - 423
Route2
- In-stock
  
  71989-18-9
- ~%
- In-stock
  
  203854-49-3
References
- Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 42, # 7 p. 1691 - 1695

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 101.93
LogP 4.4903
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 8

Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Glutamic acid and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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Fmoc-β-HoGlu(OtBu)-OH

CAS No. 203854-49-3

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