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CS-W001157 4
Total: USD 88.00

5-Chloro-2-methylpyridine

  • CAS No. 72093-07-3

  • Cat. No. CS-W005312
  • Purity≥95%
  • MDL No.MFCD04114188

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-methylpyridine|CS-W005312

Structure of 72093-07-3

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General Information

  • CAS No. 72093-07-3
  • Cat. No. CS-W005312
  • Purity ≥95%
  • MDL No. MFCD04114188
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClN
  • Molecular Weight None
  • Synonym(s) 5-chloro-2-methyl pyridine
  • SMILES CC1=NC=C(Cl)C=C1

Description

D-Mannosamine hydrochloride is used in the synthesis of non-natural Mannac analogs for the expression of thiols on cell-surface sialic acids. It is also used to investigate and screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. It acts as a precursor of N-propanoyl mannosamine and other N-acyl precursors of sialic acid (N-acyl neuraminic acids). It is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery through M cells of Peyer's patches.

Application

5-Chloro-2-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient functionalization at the pyridine ring. Its ortho-substituted structure provides enhanced regioselectivity in palladium-catalyzed couplings, while the chloro and methyl groups offer complementary handles for further derivatization. The compound exhibits good bench stability and is readily purified by distillation or chromatography, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • In-stock
      2,5-Dichloropyridine|CS-W016342
      16110-09-1
    • null|null
      594-27-4
    • ~%
    • In-stock
      5-Chloro-2-methylpyridine|CS-W005312
      72093-07-3

    References

    • WO2005/27837 A2, ; Page/Page column 66-67 ; WO 2005/027837 A2
  • Route2
    • null|null
      1199-48-0
    • ~%
    • In-stock
      5-Chloro-2-methylpyridine|CS-W005312
      72093-07-3

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 27, p. 293 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 29, p. 61 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 133, p. 36,49
  • Route3
    • null|null
      70788-54-4
    • ~%
    • In-stock
      5-Chloro-2-methylpyridine|CS-W005312
      72093-07-3

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 27, p. 293 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 29, p. 61 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 133, p. 36,49

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.04342
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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