Lot numbers can be found on the outside label of a product:
tert-Butyl methyl(prop-2-yn-1-yl)carbamate
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CAS No. 124045-51-8
- Cat. No. CS-0142817
- Purity≥95%
- MDL No.MFCD22548360
*For research and further manufacturing use only, not for direct human use.
Structure of 124045-51-8
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General Information
- CAS No. 124045-51-8
- Cat. No. CS-0142817
- Purity ≥95%
- MDL No. MFCD22548360
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₅NO₂
- Molecular Weight 169.22
- Synonym(s) tert-butyl N-methyl-N-prop-2-ynylcarbamate
- SMILES O=C(OC(C)(C)C)N(C)CC#C
Description
tert-Butyl methyl(prop-2-yn-1-yl)carbamate features a propargylic carbamate moiety flanked by a tert-butyl group and a methyl-substituted alkyne, enabling selective protection of amines under mild conditions. This stable, bench-ready reagent integrates seamlessly into multistep syntheses, delivering efficient deprotection via acidolysis without affecting other functional groups.
Application
tert-Butyl methyl(prop-2-yn-1-yl)carbamate serves as a versatile, bench-stable carbamate protecting group for amines, enabling orthogonal protection in complex molecule synthesis. Its propargylic linkage facilitates selective deprotection under mild conditions and supports efficient coupling reactions via the alkyne handle. The compound exhibits excellent functional group tolerance and simplifies purification in multistep synthetic sequences, making it well-suited for peptide derivatization and heterocycle construction.
Synthesis
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Route1
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35161-71-8 -
In-stock
24424-99-5 - ~97%
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In-stock
124045-51-8
References
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Tetrahedron, , vol. 67, # 52 p. 10082 - 10088
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Route2
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In-stock
92136-39-5 -
74-88-4
- ~94%
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In-stock
124045-51-8
References
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WO2013/169401 A1, ; Page/Page column 94 ;
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Route3
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In-stock
24424-99-5
- ~%
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In-stock
124045-51-8
References
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Tetrahedron, , vol. 65, # 31 p. 6156 - 6168
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.54
- LogP 1.4865
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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