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CS-W001157 4
Total: USD 88.00

Boc-Propargylamine

  • CAS No. 92136-39-5

  • Cat. No. CS-M0556
  • Purity≥98%
  • MDL No.MFCD07367245

*For research and further manufacturing use only, not for direct human use.

Boc-Propargylamine|CS-M0556

Structure of 92136-39-5

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General Information

  • CAS No. 92136-39-5
  • Cat. No. CS-M0556
  • Purity ≥98%
  • MDL No. MFCD07367245
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃NO₂
  • Molecular Weight 155.19
  • Synonym(s) N-Boc-Propargylamine
  • SMILES C#CCNC(OC(C)(C)C)=O

Application

Boc-Propargylamine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to propargyl-containing scaffolds under mild conditions. Its robust tert-butoxycarbonyl (Boc) protecting group offers excellent stability during multistep syntheses and can be selectively removed via acidolysis. The terminal alkyne functionality facilitates Cu-catalyzed azide-alkyne cycloaddition (CuAAC), making it ideal for click chemistry applications and the construction of diverse heterocyclic frameworks.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      2450-71-7
    • ~99%
    • In-stock
      Boc-Propargylamine|CS-M0556
      92136-39-5

    References

    • Ishida, Tomonobu; Kobayashi, Ryo; Yamada, Tohru Organic Letters, 2014 , vol. 16, # 9 p. 2430 - 2433
  • Route2
    • In-stock
      Di-tert-Butyl carbonate|CS-0146214
      34619-03-9
    • null|null
      2450-71-7
    • ~97%
    • In-stock
      Boc-Propargylamine|CS-M0556
      92136-39-5

    References

    • PFIZER PRODUCTS INC. Patent: WO2004/56830 A1, 2004 ; Location in patent: Page 86 ;
  • Route3
    • null|null
      90965-06-3
    • In-stock
      tert-Butyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate|CS-W007964
      121505-93-9
    • ~78%
    • In-stock
      Boc-Propargylamine|CS-M0556
      92136-39-5

    References

    • Dickson, Hamilton D.; Smith, Stephon C.; Hinkle, Kevin W. Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5597 - 5599

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H412
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.1443
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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