6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine

Name: 6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1234616-70-6
Cat. No. CS-0139566
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine|CS-0139566

Structure of 1234616-70-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1234616-70-6
Cat. No. CS-0139566
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₂BrCl₂N₃
Molecular Weight 278.92
Synonym(s) 6-bromo-2,4-dichloro-pyrido[2,3-d]pyrimidine
SMILES ClC1=C(C=C(Br)C=N2)C2=NC(Cl)=N1

Description

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine features a rigid heteroaromatic core with strategically positioned halogens enabling direct functionalization. The bromine at the 6-position facilitates palladium-catalyzed cross-coupling, while the 2,4-dichloro substitution provides orthogonal reactivity for sequential derivatization. This compound serves as a high-impact scaffold in kinase inhibitor development and advanced medicinal chemistry campaigns.

Application

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromine and two chloro groups provide orthogonal reactivity for sequential derivatization, while the pyridopyrimidine core offers structural rigidity and favorable electronic properties for target engagement. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for high-throughput synthesis of kinase inhibitors and other bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  142168-97-6
- ~75%
- In-stock
  
  1234616-70-6
References
- Sun, Zhihua; Wang, Han; Wen, Kun; Li, Ya; Fan, Erkang Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4149 - 4153

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 38.67
LogP 3.0941
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

1234616-70-6 sigma1234616-70-6 manufacturer1234616-70-6 price1234616-70-6 structure1234616-70-6 SDSbuy 1234616-70-61234616-70-6 supplier1234616-70-6 uses1234616-70-6 molecular weightprice of 1234616-70-61234616-70-6 chemical name formula of 1234616-70-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-Bromo-2,4-dichloropyrido[2,3-d]pyrimidine

CAS No. 1234616-70-6

Recommended Products