Fmoc-NH-PEG12-CH2CH2COOH

Name: Fmoc-NH-PEG12-CH2CH2COOH
Brand: ChemScene
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CAS No. 1952360-91-6
Cat. No. CS-0114278
Purity≥96%
MDL No.MFCD08064302

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1952360-91-6
Cat. No. CS-0114278
Purity ≥96%
MDL No. MFCD08064302
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₂H₆₅NO₁₆
Molecular Weight 839.97
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Description

Fmoc-NH-PEG12-CH2CH2COOH is a bifunctional PEGylated linker featuring an Fmoc-protected amine at one end and a terminal carboxylic acid for conjugation. This hydrophilic spacer enhances solubility in aqueous systems while enabling efficient coupling to peptides or biomolecules via standard amide bond formation. The 12-ethylene glycol unit provides flexibility and steric shielding, ideal for minimizing aggregation in bioconjugation applications.

Application

Fmoc-NH-PEG12-CH₂CH₂COOH serves as a versatile bifunctional linker for solid-phase synthesis, enabling efficient conjugation of peptides and biomolecules. The Fmoc group provides orthogonal protection for amine functionalities, while the long PEG12 spacer enhances solubility and reduces aggregation. The terminal carboxylic acid facilitates coupling to amines via standard activation methods, offering robust performance in peptide macrocyclization, antibody-drug conjugate assembly, and bioconjugation workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

TPSA 186.39
LogP 3.199
H_Acceptors 15
H_Donors 2
Rotatable_Bonds 41

Other Classifications

Life Science Crosslinking Agent

Life Science Linker Fmoc PEG

Life Science Linker PEG Acid

Building Blocks Functional Group PEG

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Bioconjugation Heterobifunctional Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Bioconjugation PEGylation Reagents and PEG Spacers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Linkers and Crosslinkers Heterobifunctional Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Linkers and Crosslinkers Heterobifunctional Cross-Linkers

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology Linkers and Crosslinkers Heterobifunctional Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation Heterobifunctional Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

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Fmoc-NH-PEG12-CH2CH2COOH

CAS No. 1952360-91-6

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