6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine

Name: 6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2417920-98-8
Cat. No. CS-0379573
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine|CS-0379573

Structure of 2417920-98-8

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General Information

CAS No. 2417920-98-8
Cat. No. CS-0379573
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆BrF₃N₂
Molecular Weight 255.04
Synonym(s) None
SMILES NC1=NC(Br)=C(C(F)(F)F)C(C)=C1

Description

6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group that enhances metabolic stability and electron deficiency, while the bromo and methyl substituents enable selective cross-coupling reactions. This pyridine scaffold serves as a key building block in pharmaceutical discovery, particularly for kinase inhibitors and bioactive heterocycles.

Application

6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. Its bromine and amine functionalities enable sequential derivatization via Pd-catalyzed coupling, while the trifluoromethyl and methyl groups confer enhanced metabolic stability and modulated lipophilicity. The compound exhibits good bench stability and facilitates efficient access to complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.75352
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Drug Discovery Cancer KRAS

Key Words

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6-Bromo-4-methyl-5-(trifluoromethyl)pyridin-2-amine

CAS No. 2417920-98-8

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