5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine

Name: 5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1196157-42-2
Cat. No. CS-W007255
Purity≥97%
MDL No.MFCD09909759

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine|CS-W007255

Structure of 1196157-42-2

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Description

5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine is a bench-stable heterocyclic scaffold featuring two strategically positioned chlorine substituents that enhance electrophilic reactivity. This electron-deficient core integrates readily into medicinal chemistry campaigns, enabling efficient coupling in cross-coupling and nucleophilic substitution reactions. Its rigid, planar structure supports π-stacking interactions, making it valuable for kinase inhibitor design and fluorescent probe development.

Application

5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine serves as a versatile building block for the synthesis of biologically active heterocycles. Its dichloro substitution pattern enables regioselective functionalization via palladium-catalyzed cross-coupling reactions, facilitating access to complex pyrazolo[4,3-d]pyrimidine scaffolds. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, supporting efficient incorporation into medicinal chemistry campaigns and API development workflows.

General Information

CAS No. 1196157-42-2
Cat. No. CS-W007255
Purity ≥97%
MDL No. MFCD09909759
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂Cl₂N₄
Molecular Weight 189.00
Synonym(s) None
SMILES ClC1=C(NN=C2)C2=NC(Cl)=N1

Computational Chemistry Data

TPSA 54.46
LogP 1.6597
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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5,7-Dichloro-1H-pyrazolo[4,3-d]pyrimidine

CAS No. 1196157-42-2

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